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陳路

專家 博士生導師

科    室 西部婦幼醫學研究院

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招生方向 其它

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簡介

1.      職稱:研究員、優秀青年

3.      研究方向:運用生物信息學的方法結合分子生物學技術研究疾病的發生機制;致力于研究可變剪接在幹細胞分化、癌症等疾病發生等方面的作用機理。

4.      郵件:luchen@scu.edu.cn

5.      個人經曆:

2011年6月- 2016年8月博士后经历 (剑桥大学,桑格研究所,英国)    

2008年10月- 2011年6月博士学位 (巴斯大学,  英国)      

6.      代表性論文:

1Chen L, Bing G, Casale F P et al. 2016. Genetic driversof epigenetic and transcriptional variation in human immune cells. Cell (inpress)

2Astle WJ, Elding H, Jiang T et al. (including Chen L). 2016. Thousands ofgenetic variants modulate blood cell variation and function in humans. Cell (inpress)

3Iotchkova V, Huang J, Morris JA et al. (includingChen L).2016.Discovery andrefinement of genetic loci associated with cardiome-x-tabolic risk using denseimputation maps. Nature genetics doi:10.1038/ng.3668.

4Polfus L M, Khajuria R K, Schick U M et al.(including Chen L). Whole-Exome Sequencing Identifies Loci Associated withBlood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants inHuman Hematopoiesis. The American Journal of Human Genetics.99(2), 481-488

5The UK10K Consortium (including Chen L). 2015.The UK10K project: rare variants in health and disease. Nature 526 (7571): 82-90

6Vasquez L, Mann L A, Chen L, Soranzo N. 2015. From GWAS to function: lessons fromblood cells. ISBT Science Series (0), 1–9

7Tovar-Corona JM, Castillo-Morales A, Chen L et al. 2015. Alternativesplice in alternative lice. Molecular biology and evolution, 32(10), 2749-2759

8ChenL,Kostadima M, Martens JH et al. 2014. Transcriptional diversity during lineagecommitment of human blood progenitors. Science345(6204): 1251033.(Highlightedin NatureReviews Genetics).

9ChenL, Bush SJ, Tovar-Corona JMet al. 2014. Correcting forDifferential Transcript Coverage Reveals a Strong Relationship betweenAlternative Splicing and Organism Complexity. Molecular biology and evolution31(6): 1402-1413.

10Shin SY, Fauman EB, Petersen AK (including Chen L) et al. 2014. An atlas ofgenetic influences on human blood me-x-tabolites. Nature genetics 46(6):543-550.

11Timpson NJ, Walter K, Min JL(including Chen L) et al. 2014. A rarevariant in APOC3 is associated withplasma triglyceride and VLDL levels in Europeans. Nat. commun.5: 4871.

12Bush SJ, Castillo-Morales A, Tovar-Corona JM, Chen L et al. 2014.Presence-Absence Variation in A-thalianaIs Primarily Associated with Genomic Signatures Consistent with RelaxedSelective Constraints. Molecular biology and evolution31(1): 59-69.

13WuXM, Tronholm A, Caceres EFincludingChen L) et al. 2013. Evidencefor Deep Phylogenetic Conservation of Exonic Splice-Related Constraints:Splice-Related Skews at Exonic Ends in the Brown Alga Ectocarpus Are Common andResemble Those Seen in Humans. Genome biology and evolution 5(9):1731-1745.

14Chen L,Tovar-Corona JM, Urrutia AO. 2012. Alternative splicing: a potential source offunctional innovation in the eukaryotic genome. Int J Evol Biol 2012:596274. (Review)

15Chen L,Tovar-Corona JM, Urrutia AO. 2011. Increased levels of noisy splicing incancers, but not for oncogene-derived transcripts. Human molecular genetics20(22): 4422-4429

16Chen L,Zhang QJ, Wang W, Wang YQ. 2010. Spatiotemporal ex-x-pression of Pax genes in amphioxus: insights into Pax-related organogenesis and evolution.SciChina Life sci 53(8): 1031-1040.


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