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曹中炜

專家 博士生導師

科    室 西部婦幼醫學研究院

是否在職 在職

招生方向 其它

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簡介

1.職稱:研究員

2.學曆:博士

3.研究方向:主要研究腫瘤微環境如何誘導和維持腫瘤幹細胞。我們認爲腫瘤的血管微環境,特別是血管內皮細胞,通過分泌旁分泌因子來調控腫瘤幹細胞的生長,遷移,化療抗性等屬性。這些發現從概念上改變了血管系統在腫瘤和纖維化中傳輸血液的傳統觀點。對血管微環境與腫瘤幹細胞相互作用的系統研究加深了目前對腫瘤和纖維化病理機制的理解。所得的理論發現可用來設計特異性針對腫瘤和纖維化組織中畸變血管微環境的治療手段,具有很強的應用價值。

4.郵件:zhongweicao@hotmail.com

5.教育經曆:南京大學學士,碩士,加州大學戴維斯分校博士,斯坦福大學,康奈爾大學博士後,講師

6.代表性論文

(1).  Cao Z,Lis R,Ginsberg M,Chavez D,Shido K,Rabbany SY,Fong GH,Sakmar TP,Rafii S,Ding BS.Targeting of the pulmonary capillary vascular niche promotes lung alveolarreparir and ameliorates fibrosis. Nat Med 2016, 22(2): 154-62.PMID 26779814


(2).  Cao Z, Ding BS,Guo P, Lee SL, Butler JM, Casey SC, Simons M, Tam W, Felsher DW, Shido K, Scandura JM, Rafii S. Angiocrine signals from tumor vascularniche induce B-Cell lymphoma invasiveness and chemoresistance. CancerCell 2014, 25(3): 1-16. PMID 24651014


Highlighted in 1) Cancer Cell 2014, 25 (3),261–263; 2) Nature Reviews Cancer14, 298 (2014) doi:10.1038/nrc3730; 3)  Science Signaling 2014, 7 (319): p. ec85.


(3).  Cao Z#, Ding BS#,Lis R, Nolan DJ, Guo P, Simons M, Penfold M, Shido K, Rabbany SY, and Rafii, S.Divergent angiocrine signals from vascular niche balance liver regeneration andfibrosis. Nature, 505(7481):97-102, 2014 (Epub 2013 Nov 20) (#equal contribution). PMID 24256728


Highlighted in 1) Science Signaling 2014, 7(307):ec7; 2) F1000Prime(article 718183961);

3) Science Translational Medicine 2014, 6(224):ec33. 4) Hepatology2014, doi:10.1002 /hep.27116.

(4).  RafiiS, Cao Z, Lis R, Chavez D, Shido K,Rabbany SY, Ding BS. Platelet-derivedSDF-1 primes the pulmonary capillary vascular niche to drive lung alveolarregeneration.NatureCell Biology 2015, 17(2):123-36. PMID 25621952


(5).  Cao Z, Fan-Minogue H, Bellovin DI, Yevtodiyenko,Arzeno J, Yang Q, Gambhir SS, Felsher DW. MYC phosphorylation, activation, andtumorigenic potential in hepatocellular carcinoma are regulated by HMG-CoAreductase. Cancer Res. 2011, 71(6): 2286-97. PMID 21262914


(6).  Ding BS, Nolan DJ,Guo P, Babazadeh AO, Cao Z,Rosenwaks Z, Crystal RG, Simons M, Sato TN, Worgall S, Shido K, Rabbany SY,Rafii S. Endothelial-derived angiocrine signals induce and sustain regenerativelung alveolarization. Cell. 2011, 147(3): 539-53.PMID 22036563


(7).  Fan-Minogue H, Cao Z, Paulmurugan R, Chan CT, Massoud TF, FelsherDW, Gambhir SS. Noninvasive molecular imaging of c-MYC activation in livingmice. Proc Natl Acad Sci U S A.2010, 107(36): 15892-7. PMID 20713710


(8).  Cao Z, Wu X, Yen L, Sweeney C, Carraway KL 3rd.Neuregulin-induced ErbB3 downregulation is mediated by a protein stabilitycascade involving the E3 ubiquitin ligase Nrdp1. Mol Cell Biol.2007, 27(6): 3280-8. PMID 17210635


(9).  Yen L, Cao Z, Wu X, Injalla ER, Baron C,Young LJ, Gregg JP, Cardiff RD, Borowsky AD, Sweeney C, Carraway KL 3rd.Loss of Nrdp1 enhances ErbB2/ErbB3-dependent breast tumor cell growth. Cancer Res. 2006, 66(23):11279-86. PMID 17145873


(10).BallifBA, Cao Z, Schwartz D, Carraway KL 3rd, Gygi SP.Identification of 14-3-3epsilon substrates from embryonic murine brain. J Proteome Res. 2006, 5(9):2372-9 PMID 16944949


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