簡介

1. 职称:研究员

2. 学历:博士

3. 研究方向: 运用系统免疫学方法研究机体对包括疟疾在内传染病的反应;利用系统生物学手段及基因修饰技术研究筛选新药、疫苗靶点。

4.郵箱:lin.jingwen@scu.edu.cn

5. 个人经历

2016年12月-至今,四川大學華西第二醫院研究员

2013年3月-2016年10月,UKMedical Research Council Career Development Fellow,The Francis Crick Institute (原National Institute forMedical Research),英国

2008年10月-2013年2月,博士,LeidenUniversity Medical Center,荷兰

6. 代表论文:

(1)         Lin JW*, Sodenkamp J, Cunningham D, et al,Langhorne J* (2017). Signatures of malaria-associated pathology revealed byhigh-resolution whole-blood transcriptomics in a rodent model of malaria. Sci Rep. (co-corresponding authors).

(2)         Brugat T, Reid AJ, Lin JW, etal (2016). Antibody-independentclonal selection regulates the establishment of chronic Plasmodium infection. NatureMicrobiology.

(3)         Capuccini B, Lin J,Talavera-López C, et al (2016). Transcriptomic profiling of microglia revealssignatures of cell activation and immune response, during experimental cerebralmalaria. Sci Rep.

(4)         Lin JW, Spaccapelo R, Schwarzer E, et al(2015). Replication of Plasmodium inreticulocytes can occur without hemozoin formation, resulting in chloroquineresistance.J Exp Med.

(5)         Salman AM,Mogollon CM, Lin JW, et al (2015).Generation of transgenic rodent malaria parasites expressing human-malariaparasite proteins. Methods Mol Biol.

(6)         Lin JW, Shaw TN, Bouchier P, et al (2014) Thesubcellular location of ovalbumin in Plasmodiumberghei blood stages influences the magnitude of T-cell responses. Infect Immun.

(7)         Ezougou CN,Ben-Rached F, Moss DK, Lin JW, et al(2014) Plasmodium falciparum Rab5B isN-terminally myristoylated and targeted to the parasite’s plasma and foodvacuole membranes. PLoS One.

(8)         Lin JW, Meireles P, PrudêncioM,et al (2013) Loss-of-function analyses definesvital and redundant functions of the plasmodium rhomboid proteasefamily. Molecular Microbiology.

(9)         Annoura T,van Schaijk BCL, Ploemen IHJ, Sajid M, LinJW, et al (2013) New members of the Plasmodium 6-Cys family have distinctand critical roles in liver stage development. FASEB J

(10)     Deroost K,Tyberghein A, Lays N, Noppen S, Schwarzer E, Vanstreels E, Komuta M, Prato M, Lin JW, et al (2013) Hemozoin induceslung inflammation and correlates with malaria-associated acute respiratorydistress syndrome. Am J Respir Cell MolBiol

(11)     Lin JW, Sajid M, Ramesar J, Khan SM, Janse CJ,Franke-Fayard B. (2011). Screening inhibitors of P. berghei blood stages using bioluminescent reporter parasites. Methods Mol Biol.

(12)     Lin JW, Annoura T, SajidM, Chevalley-Maurel S, Ramesar J, Klop O, Franke-Fayard B, Janse CJ, Khan SM(2011) A novel ‘gene insertion/marker out’ (GIMO) method for transgeneex-x-pression and gene complementation in rodent malaria parasites. PLoS One.

(13)     Balu B, Maher SP, Pance A, Chauhan C, Naumov AV, Andrews RM, Ellis PD,Khan SM, Lin JW, et al (2011)CCR4-associated factor 1 coordinates the ex-x-pression of Plasmodium falciparum egress and invasion proteins. Eukaryot Cell.

(14)     Barker RH Jr, Urgaonkar S, Mazitschek R, Celatka C, Skerlj R, CorteseJF, Tyndall E, Liu H, Cromwell M, Sidhu AB, Guerrero-Bravo JE, Crespo-Llado KN,Serrano AE, Lin JW, et al (2011)Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum. Antimicrob Agents Chemother.

(15)     Booker ML, Bastos CM, Kramer ML, Barker RH Jr, Skerlj R, Sidhu AB, DengX, Celatka C, Cortese JF, Guerrero Bravo JE, Crespo Llado KN, Serrano AE,Angulo-Barturen I, Jiménez-Díaz MB, Viera S, Garuti H, Wittlin S,Papastogiannidis P, Lin JW, et al(2010) Novel inhibitors of Plasmodiumfalciparum dihydroorotate dehydrogenase with anti-malarial activity in themouse model. J Biol Chem.



     



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