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張志新

專家 博士生導師

科    室 西部婦幼醫學研究院

是否在職 在職

招生方向 母嬰醫學/應激生物學

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簡介

1. 學曆:博士

2. Email: Jason_Zhang2011@hotmail.com

3. 研究方向:

B淋巴細胞發育和抗體産生的分子調控

細胞核骨架和B淋巴細胞基因表達以及免疫球蛋白基因重組

自身免疫疾病中諸如紅斑狼瘡和風濕性關節炎B淋巴細胞的異常功能

B淋巴細胞抗病毒反應

B淋巴瘤和白血病的發病機理

抗腫瘤抗體免疫細胞治療

4. 教育經曆

1985-1989         學士/B.S.            南開大學

1989-1992         碩士/ M.S.          南開大學

1993-1997         博士/ Ph.D.       美國阿拉巴馬大學伯明翰分校

1997-2003         博士後                美國阿拉巴馬大學伯明翰分校,Max Cooper實驗室

5.工作經曆

2015-                  四川大學華西第二醫院,教授,免疫发育和疾病治疗實驗室PI

2014-                  四川大學卓越学者特聘教授

2013-                  终身教授,美國内布拉斯加大学医学中心病理和微生物系

2011-2013         终身副教授,美國内布拉斯加大学医学中心病理和微生物系

2008-2011         副教授,美國内布拉斯加大学医学中心病理和微生物系

2003-2008         助理教授,美國阿拉巴馬大學伯明翰分校

6. 代表性論文:

(1)  Rogosch, T, KerzelS, Dey F, Wagner, J-J, Zhang Z,Maier RF, and Zemlin M. IgG4 and IgE transcripts in childhood allergic asthmareflect divergent antigen-driven selection. JImmunol, 193:5801-5808, 2014.

(2)Lange MD, Huang L, Yu Y, Li S, Liao H, Zemlin M, Su K, and Zhang Z*. Accumulation of VHReplacement Products in IgH Genes Derived from Autoimmune Diseases andAnti-Viral Responses in Human, FrontImmunol. 5:345, 2014.

(3)  Zhang B, Liang J, Zhang Z*,Role of biomarkers in management of complications after cardiac surgery. J Cardiovasc Surg (Torino). 55:1-2, 2014.

(4) Huang L, Lange MD, and Zhang Z*. VH replacement footprintanalyser-I (VHRFA-I), a Java based computer program for analyses ofimmunoglobulin heavy chain genes and potential VH replacementproducts in human and mouse. Front.Immunol. 5:40, 2014.

(5)  Shi G, Zhang J, Zhang Z, Zhang X, Systemic autoimmunediseases. Clin Dev Immunol, 2013:728574, 2013

(6)Li S, Yu Y, Yue Y, Zhang Z,Su K, Microbial infection and rheumatoid arthritis. J Clin Cell Immunol, 4:174,2013.

(7)  Li S, Yu Y, Koehn CD, Zhang Z,Su K, Galectins in the Pathogenesis of Rheumatoid Arthritis. J Clin Cell Immunol, 4:164, 2013.

(8) Liu J, Xie W, Lange M, Hong SY, SuK, and Zhang Z*, Internalization of B cell receptors (BCRs) in human EU12 muHC+immature B cells specifically alters downstream signaling events. BioMed Res International, 2013:807240, 2013.

(9) Huang X, Huang L, Peng H, Guru A, Xue W, Hong SY, Liu M, Sharma S,Fu K, Caprez AP, Swanson DR, Zhang Z,and Ding S-H, ISPTM: An iterative search algorithm for systematicidentification of post-translational modifications from complex proteomemixtures. J Proteome Res, 12:3831?3842, 2013.

(10) Liu J, Lange M, Hong SY, Xie W, Huang L, Ehrhardt G, Burrows PD, Su K,Carter R, and Zhang Z*,Regulation of VH replacement by B cell receptor (BCR)-mediatedsignaling in human immature B cells. J.Immunol. 190:5559-5566, 2013.

(11)Huang L, Lange MD, Yu Y, LiS, Su K, and Zhang Z*. Contributionof VH replacement products in mouse antibody repertoire. PLoSOne, 8:e57877, 2013.

(12) Liao H, Run F, LiuJ, Lange M, Su K, and Zhang Z*, Contribution of VH replacement products to the generation ofanti-HIV antibodies. Clinical Immunol, 146:46-55,2013.

(13) He T, Hong SY, Huang L, Xue W, Yu Z, Kwon H,Kirk M, Ding SJ, Su K, Zhang Z*.Histoneacetyltransferase p300 acetylates Pax5 and strongly enhances Pax5-mediatedtranscriptional activity. J Biol Chem.286:14137-14145. 2011.



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